How are neurons wired to form functional and plastic circuits? Meeting on Axon Guidance, Synaptogenesis & Neural Plasticity.
نویسندگان
چکیده
Institute of Zoology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland Neurobiology Section, Biological Sciences Division, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA Corresponding author. Tel: +41 44 635 4840; Fax: + 41 44 635 6879; E-mail: [email protected] Corresponding author. Tel: +1 858 534 7212; Fax: +1 858 534 6512; E-mail: [email protected]
منابع مشابه
Science in Suzhou: establishment and function of neural circuits
Marco Polo travelled to Suzhou in 1276 and recorded his impressions. One translation of his travels notes that the city contained “many persons learned in natural science, good physicians, and able philosophers” [1]. With the inception of Cold Spring Harbour Asia in 2010, science is again at the forefront in Suzhou. The October 2011 meeting organized by Barry Dickson (Institute of Molecular Pat...
متن کاملWNTs in synapse formation and neuronal circuitry.
Wnt proteins play important roles in wiring neural circuits. Wnts regulate many aspects of neural circuit generation through their receptors and distinct signalling pathways. In this review, we discuss recent findings on the functions of Wnts in various aspects of neural circuit formation, including neuronal polarity, axon guidance, synapse formation, and synaptic plasticity in vertebrate and i...
متن کاملMolecular Mechanoneurobiology: An Emerging Angle to Explore Neural Synaptic Functions
Neural synapses are intercellular asymmetrical junctions that transmit biochemical and biophysical information between a neuron and a target cell. They are very tight, dynamic, and well organized by many synaptic adhesion molecules, signaling receptors, ion channels, and their associated cytoskeleton that bear forces. Mechanical forces have been an emerging factor in regulating axon guidance an...
متن کاملSignal Transduction Mechanisms In Commissural Axon Guidance: The Role Of Intracellular Tyrosine Kinases In Netrin-Dcc/frazzled Axon Attraction
To develop a functional nervous system, neural circuits are initially established through the stepwise process of neural specification, axon guidance and synaptogenesis. Axon guidance, the process by which neurons extend axons to their final targets, relies on the presence of extracellular cues, and their respective guidance receptors. Intracellular molecules that transduce these signals are cu...
متن کاملLocal translation and directional steering in axons.
The assembly of functional neural circuits in the developing brain requires neurons to extend axons to the correct targets. This in turn requires the navigating tips of axons to respond appropriately to guidance cues present along the axonal pathway, despite being cellular 'outposts' far from the soma. Work over the past few years has demonstrated a critical role for local translation within th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- EMBO reports
دوره 10 4 شماره
صفحات -
تاریخ انتشار 2009